Glycosyltransferases encoded by viruses

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Glycosyltransferases encoded by viruses.

Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechan...

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Functional gap junction genes are encoded by insect viruses

Ichnoviruses belong to the virus family Polydnaviridae, whose members are obligately associated with certain endoparasitoid wasps. Expression of ichnovirus genes in parasitized lepidopteran hosts leads to immune suppression and is essential for successful parasitization. To date, the role of specific ichnovirus genes in alteration of host physiology has been unclear, and no cellular homologues ...

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A functional calcium-transporting ATPase encoded by chlorella viruses

Calcium-transporting ATPases (Ca(2+) pumps) are major players in maintaining calcium homeostasis in the cell and have been detected in all cellular organisms. Here, we report the identification of two putative Ca(2+) pumps, M535L and C785L, encoded by chlorella viruses MT325 and AR158, respectively, and the functional characterization of M535L. Phylogenetic and sequence analyses place the viral...

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Functional analysis of glycosyltransferases encoded by the capsular polysaccharide biosynthesis locus of Streptococcus pneumoniae serotype 14.

Bacteria belonging to the species Streptococcus pneumoniae vary in their capsule. Presently, 90 capsular serotypes are known, all possessing their own specific polysaccharide structure. Little is known about the biosynthesis of these capsular polysaccharides. The cps locus of S. pneumoniae serotype 14 was cloned. So far, 7 open reading frames have been sequenced, cps14B to cps14H. The gene prod...

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Crosstalk between ABO and Forssman (FORS) blood group systems: FORS1 antigen synthesis by ABO gene-encoded glycosyltransferases

A and B alleles at the ABO genetic locus specify A and B glycosyltransferases that catalyze the biosynthesis of A and B oligosaccharide antigens, respectively, of blood group ABO system which is important in transfusion and transplantation medicine. GBGT1 gene encodes Forssman glycolipid synthase (FS), another glycosyltransferase that produces Forssman antigen (FORS1). Humans are considered to ...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 2004

ISSN: 0022-1317,1465-2099

DOI: 10.1099/vir.0.80320-0